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  • Title: [Relationship between the expression of E-cadherin-catenins and alpha-, beta-, gamma-catenin and the metastasis and prognosis of breast cancer].
    Author: Zou W, Hu CH, Zhou JP.
    Journal: Hunan Yi Ke Da Xue Xue Bao; 2002 Dec 28; 27(6):499-502. PubMed ID: 12658921.
    Abstract:
    OBJECTIVE: To investigate the relationship between E-cadherin, alpha-, beta-, gamma-catenin expression and clinicopathological features and prognosis of breast cancer. METHODS: The expression of E-cadherin and alpha-, beta-, gamma-catenin in 40 breast cancer specimens was studied by the immunohistochemical method. The relationship between E-cadherin, alpha-, beta-, gamma-catenin expression and clinicopathological characteristics or survival time was analyzed respectively. RESULTS: The abnormal expression of E-cadherin and alpha-, beta-catenin was significantly correlated with lymph nodes and distant metastasis (P < 0.01, P < 0.05). The expression of E-cadherin and beta-catenin was also strictly correlated with surival time of breast cancer patients (P < 0.01). However, when all the four proteins (E-cadherin, alpha-, beta-, gamma-catenin) were analyzed as one group, a significant association was found between the abnormal expression of two or more of these four proteins and the metastasis and prognosis of breast cancer (P < 0.05). CONCLUSION: Lower expression of E-cadherin and beta-catenin could be used as an important marker of metastasis and prognosis of breast cancer. Moreover, when all the four proteins (E-cadherin, alpha-, beta-, gamma-catenin) are considered together, the accuracy and sensitivity predicting metastasis and prognosis of breast cancer could be increased.
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