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  • Title: Effect of alcoholic intoxication on water content and activity of Na,K-ATPase and Ca-ATPase in rat brain.
    Author: Zamai TN, Titova NM, Zamai AS, Usol'tseva OS, Yulenkova OV, Shumkova DA.
    Journal: Bull Exp Biol Med; 2002 Dec; 134(6):541-3. PubMed ID: 12660832.
    Abstract:
    We studied the effect of 2-week alcohol intoxication on water exchange and activity of Na,K-ATPase and Ca-ATPase in rat brain. Alcohol intoxication increased water content in the brain due to cell hyperhydration. It is assumed that hyperhydration results from increased Na+ content in cells due to inhibition Na,K-ATPase activity, which in turn is caused by activation of lipid peroxidation under the effect of ethanol. A possible mechanism of Na,K-ATPase inhibition.
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