These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Efficient synthesis of an enantiopure beta-lactam as an advanced precursor of thrombin and tryptase inhibitors.
    Author: Annunziata R, Benaglia M, Cinquini M, Cozzi F, Maggioni F, Puglisi A.
    Journal: J Org Chem; 2003 Apr 04; 68(7):2952-5. PubMed ID: 12662075.
    Abstract:
    A new and efficient synthesis of a beta-lactam that is an advanced precursor of inhibitors of thrombin and tryptase is reported. The reaction sequence is based on the use of an inexpensive enantiomerically pure starting material and is designed to allow access to both enantiomers of the target molecules by epimerization of a side-product obtained along the synthesis. An improved procedure for the epimerization step that takes advantage of the use of a polymer-supported and recyclable phase-transfer catalyst is described.
    [Abstract] [Full Text] [Related] [New Search]