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  • Title: New acetylenic acids from the marine sponge Stelletta species.
    Author: Zhao Q, Lee SY, Hong J, Lee CO, Im KS, Sim CJ, Lee DS, Jung JH.
    Journal: J Nat Prod; 2003 Mar; 66(3):408-11. PubMed ID: 12662102.
    Abstract:
    Four new acetylenic acids were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of CD spectroscopy and a chiral anisotropic reagent, phenylglycine methyl ester (PGME). The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines and exhibited marginal to moderate cytotoxicity.
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