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  • Title: New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.
    Author: Prakash Chaturvedula VS, Schilling JK, Johnson RK, Kingston DG.
    Journal: J Nat Prod; 2003 Mar; 66(3):419-22. PubMed ID: 12662105.
    Abstract:
    Bioassay-guided fractionation of a CH(2)Cl(2)-MeOH extract of the twigs of Coussarea paniculata using a yeast-based assay for potential DNA-damaging agents resulted in the isolation of three new lupane triterpenoids, 1-3, in addition to eight known triterpenoids, lupeol (4), lupeyl acetate (5), betulin (6), betulinic acid (7), 3-epi-betulinic acid (8), 3-epi-betulinaldehyde (9), oleanolic acid (10), and ursolic acid (11). The structures of the new compounds were established as lup-20(29)-en-3beta,25-diol (1), lup-20(29)-en-11alpha-ol-25,3beta-lactone (2), and 3-deoxybetulonic acid (3), on the basis of extensive 1D and 2D NMR spectroscopic data interpretation and chemical conversion.
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