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  • Title: In vivo changes in the intestinal lipid peroxidation and the crypt response to whole-body gamma irradiation in diethylnitrosamine-treated mice.
    Author: Grudziński IP.
    Journal: Rocz Panstw Zakl Hig; 2002; 53(4):333-40. PubMed ID: 12664660.
    Abstract:
    Studies were carried out to elucidate lipid peroxidation and crypt survival in the small intestinal mucosa of mice pretreated per os with diethylnitrosamine (DENA) and whole-body gamma irradiated. Results show that DENA lowered the total value of mean lethal radiation dose for crypt cells, and the agent was enable to sensitize crypts to gamma-rays. Present data suggest that gamma radiation- and/or DENA-induced pro-oxidant shift(s) is a risk factor for crypt survival.
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