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  • Title: [Influence of endothelial cells on the proliferation of scar-derived fibroblast in hypertropic scar tissue].
    Author: Zhang L, Guo S, Xia W, Yang L, Wang Z.
    Journal: Zhonghua Zheng Xing Wai Ke Za Zhi; 2002 Nov; 18(6):338-40. PubMed ID: 12664798.
    Abstract:
    OBJECTIVE: To investigate the influence of the endothelial cells on the scar-derived fibroblasts in the hypertropic scar tissue. METHODS: The endothelial cell from the human umbilical vein was cultured and its supernatant was then collected. Thereafter, it was mixed with the pre-cultured scar-derived fibroblasts from the hypertropic scar tissue. The fibroblasts were analyzed with a flow cytometer in a MTT-assay method to evaluate the cell proliferation and its division cycle. RESULTS: The endothelial cells were significantly increasing the scar-derived fibroblast proliferation (P < 0.05), compared with the control. The proportion of the fibroblasts in the S-stage of cell cycle was also quite high. CONCLUSION: The endothelial cells may secrete some active products, which may enhance the proliferation of the scar-derived fibroblasts and stimulate the fibroblasts into the S-stage of cell generation cycle.
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