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  • Title: Pure red cell aplasia in a Sjögren's syndrome/lupus erythematosus overlap patient.
    Author: Mavragani CP, Vlachaki E, Voulgarelis M.
    Journal: Am J Hematol; 2003 Apr; 72(4):259-62. PubMed ID: 12666137.
    Abstract:
    Hematological complications of systemic lupus erythematosus usually include anemia of chronic disease and peripheral destruction of blood cells. We describe the case of a young woman with Sjögren's syndrome'lupus erythematosus overlap, mother of infant with congenital heart block, complicated by pure red cell aplasia. The patient was asymptomatic until the onset of severe anemia. A serum inhibitor of erythropoiesis was detected before the onset of immunosuppression. Bone marrow examination showed a low CD4:CD8 ratio, an immune defect possibly linked with the unrestrained production of antibodies against erythroid progenitor cells.
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