These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Correlation between epidermal growth factor and overexpression of vascular endothelial growth factor in hepatocellular carcinoma].
    Author: Huang G, Yang L, Yang J, Liu H, Yang Z.
    Journal: Zhonghua Zhong Liu Za Zhi; 2002 Nov; 24(6):564-6. PubMed ID: 12667326.
    Abstract:
    OBJECTIVE: To investigate the correlation between epidermal growth factor (EGF) and overexpression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). METHODS: Expressions of EGF, VEGF and microvessel density were studied through immunohistochemical SABC method in 36 HCC specimens, their paraneoplastic liver tissues and 6 normal liver tissues with the correlation between these parameters analyzed. Recombinant human EGF was used to stimulate HepG(2) cells and semi-quantitative reverse transcription PCR was adopted to detect the expression of VEGF in HepG(2) cells. RESULTS: The positive rates of EGF and VEGF expression in HCC tissue were 75.0% and 88.9%. There was positive correlation between EGF and VEGF expression (P < 0.01, r = 0.462). Recombinant human EGF could induce the expression of VEGF in HepG(2) cells in a dose and time dependent manner. CONCLUSION: The expression of EGF in HCC underlies the overexpression of VEGF in HCC.
    [Abstract] [Full Text] [Related] [New Search]