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  • Title: [Effects of salicylate on the capillary permeability of inner ear in guinea pigs].
    Author: Zhu J, Liu Z.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2002 Dec; 16(12):687-8. PubMed ID: 12669447.
    Abstract:
    OBJECTIVE: To further understand the mechanism of salicylate ototoxicity. METHOD: The capillary permeability of inner ear was compared between the normal group and the salicylate ototoxicity group traced with lanthanum by electron microscopy. RESULT: The normal inner/outer spiral vessels of basilar membrane, strial blood vessels had no permeability, whereas the capillaries of endolymphatic sac showed a certain permeability. In salicylate ototoxicity group, the permeability of the capillaries mentioned above increased significantly. CONCLUSION: Salicylate may increase the capillary permeability in inner ear, which may participate in the mechanism of the salicylate ototoxicity.
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