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  • Title: Histopathological study of dental pulp tissue capped with enamel matrix derivative.
    Author: Ishizaki NT, Matsumoto K, Kimura Y, Wang X, Yamashita A.
    Journal: J Endod; 2003 Mar; 29(3):176-9. PubMed ID: 12669875.
    Abstract:
    The purpose of this study was to examine the histopathological response of dental pulp tissue to enamel matrix derivative (EMD) used as a pulp capping material. Thirty-two teeth from two mongrel dogs were divided into four equal groups. One group served as controls, and the others were used for deep Class V cavity preparation followed by direct pulp capping with enamel matrix derivative. The treated teeth were extracted after 1, 4, and 8 weeks and prepared for histopathological examination by light microscopy. All teeth prepared after 4 and 8 weeks demonstrated an increase in tertiary dentin, suggesting that enamel matrix derivative exerts a considerable influence on odontoblasts and endothelial cells of capillaries in dental pulp tissue. These results imply that enamel matrix derivative used as a pulp capping material may play a role in the calcification of dental pulp tissue.
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