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  • Title: [Gene mapping of a nonsyndromic hearing impairmint family].
    Author: Cheng L, Gong Y, Liu Q, Chen B, Guo C, Li J, Zhang X, Lu Y, Gao G, Zhou H, Guo Y.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2003 Apr; 20(2):89-93. PubMed ID: 12673573.
    Abstract:
    OBJECTIVE: To map the gene responsible for nonsyndromic hearing impairment in a consanguineous family. METHODS: Firstly, X chromosome scanning was used to exclude X chromosome. Secondly, candidate gene analyzing and genome scanning were performed by homozygosity mapping. Then, additional markers flanking the tightly linked marker were tested to confirm linkage and decide the candidate region. RESULTS: The nonsyndromic hearing impairment of this family was autosomal recessive. Twenty-five known genes were excluded. Autosomal genome scanning indicated that D17S1293 was tightly linked with disease gene. And further study mapped the disease gene to a 5.07 cM interval bounded by D17S1850 and D17S1818. CONCLUSION: The disease gene of the family is mapped to a 5.07 cM interval between D17S1850 and D17S1818, which is a new locus of autosomal recessive nonsyndromic hearing impairment.
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