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  • Title: [Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women].
    Author: Chen J, Zhang L, Qiu J, Peng H, Deng Z, Wang Y, Yan Z.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2003 Apr; 20(2):167-8. PubMed ID: 12673591.
    Abstract:
    OBJECTIVE: To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women. METHODS: The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women. RESULTS: In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85.71%, 14.29% and 0, respectively (P>0.05). CONCLUSION: Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study.
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