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  • Title: Antenatal manifestation of congenital pancreatoblastoma in a fetus with Beckwith-Wiedemann syndrome.
    Author: Pelizzo G, Conoscenti G, Kalache KD, Vesce F, Guerrini P, Cavazzini L.
    Journal: Prenat Diagn; 2003 Apr; 23(4):292-4. PubMed ID: 12673632.
    Abstract:
    Antenatal detection of an isolated abdominal cyst was found to be a pancreatoblastoma in a female fetus with Beckwith-Wiedemann syndrome. Prenatal and post-natal features and management of this very rare tumour are discussed. Molecular investigation disclosed a mosaic paternal 11p15 uniparental disomy in the tumoral cells. The prognosis of a congenital pancreatoblastoma is good if complete surgical excision is achieved. However, the association with Beckwith-Wiedemann syndrome requires a prolonged follow-up because of the increased risk of developing malignant tumours.
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