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  • Title: Hemostatic alterations in sickle cell disease: relationships to disease pathophysiology.
    Author: Stuart MJ, Setty BN.
    Journal: Pediatr Pathol Mol Med; 2001; 20(1):27-46. PubMed ID: 12673843.
    Abstract:
    The protean manifestations of sickle cell disease (SCD), especially, microvessel involvement in the vaso-occlusive process, is classically ascribed to the phenomena of erythrocyte sickling and enhanced red cell-endothelial adherence. Pertubations in various hemostatic systems occurs in SCD, both in steady state and during vaso-occlusion, with the intravascular generation of thrombin. The etiology(s) of thrombin generation in SCD will be described. Whether the activation of the cellular and plasmatic phases of hemostasis is causative or occurs as a result of vascular injury will be discussed.
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