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  • Title: RAS and connective tissue in the heart.
    Author: Sun Y, Weber KT.
    Journal: Int J Biochem Cell Biol; 2003 Jun; 35(6):919-31. PubMed ID: 12676176.
    Abstract:
    Circulating angiotensin (Ang) II has well-known endocrine properties in the cardiovasculature. AngII, produced de novo within the heart, has various autocrine and paracrine properties on resident cells expressed via AT(1) receptor-ligand binding. Herein, we review the heart's renin-angiotensin system and its role in connective tissue turnover involving heart valve leaflets and fibrous tissue that appears at sites of injury, such as following myocardial infarction.
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