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  • Title: [Apolipoprotein E polymorphism as a predictor of progression of multiple sclerosis].
    Author: Guerrero AL, Bueno V, Hernández MT, Martín-Serradilla JI, Carrasco E, Cuadrado I.
    Journal: Neurologia; 2003 Apr; 18(3):146-8. PubMed ID: 12677480.
    Abstract:
    INTRODUCTION: During recent years, different studies have proposed that apolipoprotein E e4 can be a predictor of progression in multiple sclerosis. We aim to evaluate these findings in our country. PATIENTS AND METHODS: We studied 42 patients with relapsing remitting or secondary progressive multiple sclerosis, and a disease duration of at least 2 years. We correlated the presence or absence of e4 allele with markers of progression such as age of onset and diagnosis, disease duration, number of relapses, EDSS at 1, 2, 5 and 10 years, progression index and relapse rate. RESULTS: None of the parameters evaluated significantly correlate with e4 allele of the APOE. CONCLUSIONS: In spite of the limitation due to the small number of patients studied, we cannot confirm that APOE e4 allele is a predictor of progression of disability in multiple sclerosis.
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