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  • Title: New cytotoxic triterpene acids from aboveground parts of Manihot esculenta from the Suriname rainforest.
    Author: Chaturvedula VS, Schilling JK, Malone S, Wisse JH, Werkhoven MC, Kingston DG.
    Journal: Planta Med; 2003 Mar; 69(3):271-4. PubMed ID: 12677535.
    Abstract:
    Two novel triterpene acids, esculentoic acid A ( 1) and B ( 2) as well as the seven known compounds 3 - 9 were isolated from an EtOAc extract of leaves, stems, and twigs of Manihot esculenta by bioassay-guided fractionation for cytotoxic activity. The structures of the two new compounds were established as 3alpha-hydroxytaraxer-14-en-29-oic acid ( 1) and 3-oxotaraxer-14-en-29-oic acid ( 2) on the basis of 1D and 2D NMR spectroscopic data interpretation and chemical conversions. The two new compounds 1 and 2 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line.
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