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  • Title: [Comparative experimental study of antiemetic action of latranum in radiation-induced vomiting and vomiting caused by apomorphine].
    Author: Martirosov KS, Grigor'ev IuG, Zorin VV, Borovkov MV.
    Journal: Radiats Biol Radioecol; 2003; 43(1):60-4. PubMed ID: 12677660.
    Abstract:
    The experiments on dogs showed that Latranum, a selective blocker of serotonin 5-HT3-receptors, has a moderate capacity to modify emetic reaction caused by dophamin-stimulating action of Apomorphinum. These results, taking in account of our preliminary experimental data obtained by a model of early radiation-induced emetic reactions, show that the high antiemetic effect of Latranum may affect another mechanisms of the initiation of early radiation-inducing vomiting which do not connect immediately with the chemoreceptor trigger zone.
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