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  • Title: A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor 4.
    Author: Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E.
    Journal: Protein Pept Lett; 2003 Apr; 10(2):133-8. PubMed ID: 12678810.
    Abstract:
    We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4[29-39]. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4[29-39].
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