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  • Title: Prognostic significance of tumor necrosis factor receptor in colorectal adenocarcinoma.
    Author: Yoshimura H, Dhar DK, Nakamoto T, Kotoh T, Takano M, Soma G, Nagasue N.
    Journal: Anticancer Res; 2003; 23(1A):85-9. PubMed ID: 12680198.
    Abstract:
    BACKGROUND: The expression pattern and prognostic impact of tumor necrosis factor receptor type 1 (TNFR1) in colorectal cancers are not known. PATIENTS AND METHODS: Immunohistochemical evaluation of TNFR1, Ki-67 and apoptosis was performed on formalin-fixed, paraffin-embedded specimens from 56 curatively-resected Dukes' stage C-colorectal cancer patients. RESULTS: Thirty-seven (66%) cases had a high expression and 19 (34%) cases had a low expression of TNFR1. Expression of TNFR1 had no significant correlation with any of the clinicopathological factors studied except tumor differentiation status. Patients with a high TNFR1 expression had a significantly better disease-specific survival rate than those with a low TNFR1 expression (77.8% vs. 60.3%, respectively, p = 0.0159, log-rank test). Also in the multivariate analysis, TNFR1 expression was an independent prognostic factor. CONCLUSION: A high TNFR1 expression in Dukes' stage C colorectal cancer could be a favorable indicator of prognosis.
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