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  • Title: Expression pattern of cisplatin-induced metallothionein isoforms in squamous cell carcinoma.
    Author: Nakano M, Sogawa CA, Sogawa N, Mishima K, Yamachika E, Mizukawa N, Fukunaga J, Kawamoto T, Sawaki K, Sugahara T, Furuta H.
    Journal: Anticancer Res; 2003; 23(1A):299-303. PubMed ID: 12680227.
    Abstract:
    Cisplatin (CDDP) is a useful drug for the treatment of malignant solid tumors of the head and neck. Because CDDP includes the heavy metal platinum as a component, it is thought metallothionein (MT) may be involved in CDDP-resistance. However, functional differences between the four MT isoforms (MT-I, II, III and IV) remain unclear. The aim of this study was to investigate the relationship between MT isoform expression and CDDP-resistance. Two human tongue squamous cell carcinoma cell lines not exposed to anticancer chemotherapy were studied. The cell lines were subjected to reverse transcriptase-polymerase chain reaction (RT-PCR) analysis before and after CDDP-treatment. Both cell lines expressed MT-I/II and MT-IV isoforms but not the MT-III isoform. Following CDDP treatment, MT-I/II mRNA levels were induced only in the CDDP-resistant cell line. Our results showed that expression of the MT I/II isoform was induced by CDDP treatment, and may play an important role in CDDP-resistance in squamous cell carcinoma of the human tongue.
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