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  • Title: The binding potential between the cholera toxin B-oligomer and its receptor.
    Author: Cai XE, Yang J.
    Journal: Biochemistry; 2003 Apr 15; 42(14):4028-34. PubMed ID: 12680755.
    Abstract:
    Employing atomic force microscopy as an in situ molecular force probe, we have measured the binding strength between cholera toxin B-pentamer (ctB) and its membrane receptor, ganglioside G(M1). By application of the basic principle of the reaction rate theory, key parameters of the ligand-receptor binding potential can be obtained from our data. The potential has a well with a spatial span of about 2.5 A and a depth of at least six times the thermal energy at room temperature. The very short range nature of the binding potential leads to the specificity of the ctB-G(M1) coupling.
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