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  • Title: The effects of dietary histidine, methionine and homocystine on vitamin B12 and folate levels in rat liver.
    Author: Williams DL, Spray GH.
    Journal: Br J Nutr; 1976 May; 35(3):299-307. PubMed ID: 1268182.
    Abstract:
    1. L-histidine (20 g/kg) added to vitamin B12-deficient and cyanocobalamin-supplemented diets based on soya-bean flour reduced the growth of rats given the vitamin B12-deficient diet but stimulated growth of rats given the cyanocobalamin-supplemented diet. Liver weight (g/kg body-weight)increased, but the protein content of the livers decreased, in rats given histidine supplements. The histidine was associated with significantly higher folate concentrations in the livers of cyanocobalamin-supplemented rats.
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