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  • Title: Meningioma showing VHL gene inactivation in a patient with von Hippel-Lindau disease.
    Author: Kanno H, Yamamoto I, Yoshida M, Kitamura H.
    Journal: Neurology; 2003 Apr 08; 60(7):1197-9. PubMed ID: 12682336.
    Abstract:
    The genetic mechanism of the tumorigenesis of meningioma in conjunction with von Hippel-Lindau (VHL) disease is unclear. The authors present a case of VHL disease associated with a posterior fossa meningioma and with multiple cerebellar hemangioblastomas. A germline mutation of the VHL gene and loss of heterozygosity on the VHL gene locus in 3p were detected in the meningioma. Tumorigenesis of a meningioma associated with VHL disease could be caused by inactivation of both alleles of the VHL gene.
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