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  • Title: [Pharmacological properties of 11-deoxymisoprostol].
    Author: Sapozhnikova TA, Zarudiĭ FS, Karachurina LT, Makara NS, Khisamutdinova RIu, Shaĭnurova AM, Ivanova NA, Miftakhov MS.
    Journal: Eksp Klin Farmakol; 2003; 66(1):34-6. PubMed ID: 12683078.
    Abstract:
    11-Deoxymisoprostol showed gastroprotector activity on the acute models of ulcers induced by acetylsalicylic acid and ethanol and produced curative effect on the chronic ulceration model induced by acetic acid. The positive effect is manifested by a decrease in the number of destructions and in the total area of chronic damage in the mucous membrane of the stomach. In addition, 11-deoxymisoprostol showed antiphlogistic activity on the acute edema models induced by carrageenan and formalin, by decreasing the model foot edema growth in experimental animals. The drug also decreased the level of lipid peroxidation in the rat blood serum on the background of acute ethanol ulceration.
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