These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effect of stimulation and depression of macrophages on development of paracetamol-induced acute toxic hepatitis in rats].
    Author: Levina OA, Goncharova IA, Filatova TG, Nadeev AN, Korolenko TA, Sukhenko TG, Kolesnikova OP.
    Journal: Eksp Klin Farmakol; 2003; 66(1):57-9. PubMed ID: 12683084.
    Abstract:
    The role of macrophage (Kupffer cell) stimulation and suppression in the development of a toxic liver damage was studied in rats with acute hepatitis induced by paracetamol (acetaminophen, 1000 mg/kg). Pretreatment with carboxymethylated (1-->3)-beta-D-glucan (25 mg/kg, i.p., 48 h before paracetamol) for the macrophage stimulation or with gadolinium chloride (GdCl3, 7.5 mg/kg, i.v., 24 h before paracetamol) for the macrophage suppression has a protective effect manifested by normalization of the liver function test parameters and by a decrease in the degree of morphological changes in the liver cells. A relation between these positive effects and the TNF-alpha secretion by macrophages is discussed.
    [Abstract] [Full Text] [Related] [New Search]