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  • Title: [Non-specific resistance and immune responsiveness in patients with ischemic heart disease and cardiac arrhythmias].
    Author: Anikin VV, Kalinkin MN, Voronaia IuL.
    Journal: Klin Med (Mosk); 2003; 81(2):48-51. PubMed ID: 12685236.
    Abstract:
    Nonspecific resistance (peripheral leukogram, integral leukocytic indices, types of adaptive responses, and phagocytosis) and immunological responsiveness (T- and B-immunity systems) were studied in 30 patients with chronic coronary heart disease (CHD) concurrent with various cardiac arrhythmia. In the patients, there was an increase in the relative counts of band neutrophils and lymphocytes, a decrease in the counts of segmented granulocytes and monocytes. A number of integral leukocytic indices (leukocytic index, lymphocytic-and-granulocytic index, total index, and deviation index) were increased and the neuthrophil/lymphocyte ratio was decreased. A higher frequency of a reactivation response and a lower frequency of a training response were revealed in the structure of their adaptive reactions. The patients with CHD concurrent with arrhythmia were also found to have increased granulopectic and phagocytic indices and higher tetrazolium nitroblue test values than healthy individuals. Their immunological responsiveness was characterized by a reduction in the absolute and relative counts of theophylline-sensitive T lymphocytes and an elevation of immunoglobulins A concentrations.
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