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  • Title: [Effect of adepren on the behavior and brain catecholamines of rats in an open field setup].
    Author: Stefanova D, Tiutiulkova N, Nikolova M.
    Journal: Eksp Med Morfol; 1976; 15(1):42-6. PubMed ID: 1269462.
    Abstract:
    The authors carried out experimental studies with the Bulgarian preparat on Adepren on the behaviour of rats in open field procedure together with parallel electroencephalographic studies and examined the changes in the content of cerebral catecholamines during acute and chronic administration. The preparation after single application had depresive effect on both components of the motor activity: horisontal and vertical. The horizontal component of the motor activity surpassed the norm with almost 20% at the end of the experimental period after chronic administration. There was desynchronizing effect in the KEG recordings. Adepren after acute and chronic application elevated significantly the level of noradrenaline and dopamine in the brain. The obtained results gave a foundation to the authors to suggest that the examined preparation and maoinhibiting effect.
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