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  • Title: Expression of interleukin 6 in synovial tissues in patients with internal derangement of the temporomandibular joint.
    Author: Sato J, Segami N, Nishimura M, Demura N, Yoshimura H, Yoshitake Y, Nishikawa K.
    Journal: Br J Oral Maxillofac Surg; 2003 Apr; 41(2):95-101. PubMed ID: 12694701.
    Abstract:
    Using an immunohistochemical technique, we examined synovial tissue from 46 temporomandibular joints (TMJ) with internal derangement in 44 patients. As controls, we examined synovial tissue specimens from 7 joints with habitual dislocation without pain. In synovial tissues from 21 of the 46 joints with internal derangement, interleukin 6 (IL-6) was expressed in the synovial lining cells and in the mononuclear cells infiltrating the periphery of the blood vessels. The density of IL-6-stained cells in specimens with internal derangement correlated significantly with the grade of joint effusion shown by magnetic resonance imaging (P=0.01, r=0.32).
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