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  • Title: The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat.
    Author: Walker RJ, Kemp JA, Yajima H, Kitagawa K, Woodruff GN.
    Journal: Experientia; 1976 Feb 15; 32(2):214-5. PubMed ID: 1269616.
    Abstract:
    Extracellular recordings were made from neurones in the mesencephalic reticular formation and substantianigra of the rat which was anaesthetized with urethane 1.5-2 g/kg i.p. Out of 44 cells tested 42 were excited by Substance P applied iontophoretically and in some cases this excitation was rapid. Evidence is presented for Substance P as a putative excitatory transmitter onto reticular and nigral neurones possibly released from primary sensory afferents.
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