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  • Title: [Expression of CXCR4 and its effect on the biological behavior of multiple myeloma cells].
    Author: Li CX, Wu DP, Wang YD, Yu GH, Liu JM, Zhuang YM, Yin CS, Zhang XG.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2003 Mar; 24(3):122-5. PubMed ID: 12697121.
    Abstract:
    OBJECTIVE: To investigate the effect of stromal cell derived factor-1alpha(SDF-1alpha) expression and its receptor CXCR4 on the biological behavior of multiple myeloma (MM) cells and on the expression of soluble intercellular adhesion molecule 1 (ICAM-1). METHODS: FACS analysis was used to study the expression of ICAM-1 (CD(54)) and CXCR4 on the surface of MM cells. Chemotaxis assay through transwell bore polycaronate and ELISA assay were employed to monitor the soluble ICAM-1 level. RESULTS: (1) Fresh MM cells expressed variable levels of functional CXCR4 [(50.4 +/- 27.3)%], which was correlated with the in vitro ability of transwell migration of MM cells [(23.6 +/- 17.2)%, P < 0.01]. (2) SDF-1alpha could up-regulate the expression of ICAM-1 on MM cells. Furthermore, the serum level of sICAM-1 was correlated with the expression of CXCR4 on MM cells. CONCLUSION: SDF-1alpha/CXCR4 plays an important role on the biological behavior of MM cells via mediating the effect of adhesion molecules.
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