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  • Title: Expression of CD94-NKG2A inhibitory receptor is restricted to a subset of CD8+ T cells.
    Author: Braud VM, Aldemir H, Breart B, Ferlin WG.
    Journal: Trends Immunol; 2003 Apr; 24(4):162-4. PubMed ID: 12697440.
    Abstract:
    Natural killer (NK)-cell receptors (NKRs) on CD8+ T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-cell receptor (TCR) engagement, commitment to CD94-NKG2A expression is a clonal attribute. NKRs can therefore shape cytotoxic T-lymphocyte (CTL) responses and should be considered in designing vaccine therapies.
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