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  • Title: An inherited defect in granulocyte function: impaired chemotaxis, phagocytosis and intracellular killing of microorganisms.
    Author: Niethammer D, Dieterle U, Kleihauer E, Wildfeuer A, Haferkamp O, Hitzig WH.
    Journal: Helv Paediatr Acta; 1976 Apr; 30(6):537-41. PubMed ID: 1270326.
    Abstract:
    The neutrophil granulocytes of a 1-year-old boy with severe recurrent infections were found to have almost no chemotactic responsiveness, impaired phagocytosis and reduced intracellular killing of Candida albicans "in vitro". During the course of a febrile illness of unknown etiology which was accompanied by a leukemoid reaction, phagocytic activity became normal; the chemotactic response was also increased but still remained slightly subnormal. Family studies suggested that the defect was an inherited autosomal recessive one.
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