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  • Title: Imaging single mammalian cells with a 1.5 T clinical MRI scanner.
    Author: Foster-Gareau P, Heyn C, Alejski A, Rutt BK.
    Journal: Magn Reson Med; 2003 May; 49(5):968-71. PubMed ID: 12704781.
    Abstract:
    In the present work, we demonstrate that the steady-state free precession (SSFP) imaging pulse sequence FIESTA (fast imaging employing steady state acquisition) used in conjunction with a custom-built insertable gradient coil and customized RF coils can be used to detect individual SPIO-labeled cells using a commonly available 1.5 T clinical MRI scanner. This work provides the first evidence that single-cell tracking will be possible using clinical MRI scanners, opening up new possibilities for cell tracking and monitoring of cellular therapeutics in vivo in humans.
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