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  • Title: Repression of heme oxygenase-1 expression as a defense strategy in humans.
    Author: Shibahara S, Nakayama M, Kitamuro T, Udono-Fujimori R, Takahashi K.
    Journal: Exp Biol Med (Maywood); 2003 May; 228(5):472-3. PubMed ID: 12709571.
    Abstract:
    Heme oxygenase-1 (HO-1) is an essential enzyme in heme catabolism and is characterized by its inducibility in response to various environmental factors, including its substrate heme. The induction of HO-1 has been established as the defense mechanism against oxidative stress. However, striking interspecies or inter-tissue differences are noted in the regulation of HO-1 expression under hypoxia or heat shock, each of which represses HO-1 expression in many types of human cells but rather induces it in rodent cells. The downregulation of HO-1 expression may reduce energy expenditure and local production of carbon monoxide, iron, and bilirubin and transiently increase intracellular heme pool. Here, we discuss the repression of HO-1 expression as a potential defense strategy in humans by highlighting a regulatory role of HO-1 in its own expression.
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