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  • Title: Transoral carbon-dioxide laser resection of hypopharyngeal carcinoma.
    Author: Rudert HH, Höft S.
    Journal: Eur Arch Otorhinolaryngol; 2003 Apr; 260(4):198-206. PubMed ID: 12709803.
    Abstract:
    In hypopharyngeal carcinoma, open partial resection is rarely feasible because of the high rate of chronic aspiration. Transoral laser surgery, however, is not associated with major swallowing problems. Between 1991 and 1995, a total of 29 patients with cancer of the hypopharynx were treated using laser surgical resection. In 25 patients, a neck dissection was performed, and 26 patients were radiated postoperatively. The 5-year overall survival was 48% and tumor-related survival 58%. The outcome was significantly ( P<0.048) dependent on the preoperative lymph node status (N(0)=74%, N(+)=34% overall survival). Accordingly, the 5-year survival in stage I and stage II tumors was 71% and in stage III and IV tumors 47%. The highest local control rate was achieved in patients with carcinoma of the hypopharyngeal walls. A major advantage of laser surgery is that resurfacing of the wounds takes place per secundam. No reconstructions with free vascularized grafts have to be performed. There were no functional deficits regarding speech and swallowing in 94%, 100% and 100% of the surviving patients without local recurrence after 3, 4 and 5 years, respectively. No patient had to have a tracheostomy intraoperatively. Laser surgical treatment in combination with neck dissection and postoperative radiotherapy of selected patients with early cancer of the hypopharynx shows comparable results with open surgical procedures and is superior to radiotherapy alone. Given the low postoperative morbidity, transoral laser surgery with the goal of preserving the larynx should gain more importance in the future.
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