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  • Title: Cytotoxic styrylpyrones from Goniothalamus amuyon.
    Author: Lan YH, Chang FR, Yu JH, Yang YL, Chang YL, Lee SJ, Wu YC.
    Journal: J Nat Prod; 2003 Apr; 66(4):487-90. PubMed ID: 12713398.
    Abstract:
    Two new styrylpyrones, (6R,7R,8R)-8-methoxygoniodiol (1) and (6R,7R,8R)-8-chlorogoniodiol (2), together with seven known styrylpyrones and eight other known compounds, were isolated from the leaves and/or stems of Goniothalamus amuyon. The structures of 1 and 2 were elucidated by spectral data interpretation, and the absolute stereochemistry of styrylpyrones in the diol and triol series was confirmed by X-ray crystallographic analysis and CD spectral data. Compound 2 demonstrated significant selective cytotoxicity toward the HONE-1 cancer cell line.
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