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  • Title: Sesquiterpenoids from Artemisia gilvescens and an anti-MRSA compound.
    Author: Kawazoe K, Tsubouchi Y, Abdullah N, Takaishi Y, Shibata H, Higuti T, Hori H, Ogawa M.
    Journal: J Nat Prod; 2003 Apr; 66(4):538-9. PubMed ID: 12713410.
    Abstract:
    A new secoguaianolide sesquiterpene (1) was isolated along with its three stereoisomers (2-4) from the nonmedicinal plant Artemisia gilvescens. The structure of 1 was elucidated to be (4S,5S)-dihydro-5-[(1R,2S)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone on the basis of 2D NMR and other spectroscopic evidence. Five known sesquiterpenoids were also isolated from this plant, and one of them (5) showed activity against methicillin-resistant Staphylococcus aureus (MRSA).
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