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  • Title: Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines.
    Author: Fukunaga JY, Hansch C, Steller EE.
    Journal: J Med Chem; 1976 May; 19(5):605-11. PubMed ID: 1271401.
    Abstract:
    A quantitative structure-activity relationship (QSAR) has been formulated for quinazolines causing 50% inhibition of liver dihydrofolate reductase. The QSAR for the quinazolines is compared with QSAR for triazine and pyrimidine inhibitors. The three QSAR suggest new possibilities for the design of inhibitors of mammalian dihydrofolate reductase.
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