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  • Title: Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography.
    Author: Mirrlees MS, Moulton SJ, Murphy CT, Taylor PJ.
    Journal: J Med Chem; 1976 May; 19(5):615-9. PubMed ID: 1271403.
    Abstract:
    A technique is presented for the direct measurement of octanol-water partition coefficients by HPLC. The method involves running solutes in octanol-saturated water as the mobile phase against water-saturated octanol entrained on an inert support. Log P correlates linearly with log tc for a number of standards. The measurable range in log P (so far) is -0.3 to +3.7. A critical review of chromatographic methods in Hansch analysis is given.
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