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  • Title: [Analysis of sperm chromosomes in infertile males with teratozoospermia].
    Author: Szczygieł MA, Kusakabe H, Wiland E, Kurpisz M.
    Journal: Ginekol Pol; 2003 Feb; 74(2):108-15. PubMed ID: 12715419.
    Abstract:
    OBJECTIVES: The aim of the study was to examine sperm chromosomes from infertile males with teratozoospermia. DESIGN: Basic research study MATERIALS AND METHODS: Spermatozoa were obtained from infertile males with teratozoospermia. Intracytoplasmic sperm injection was used to inject human spermatozoa into mouse oocytes in order to examine sperm chromosomes. RESULTS: Chromosomes of spermatozoa obtained from 6 infertile teratozoospermic and 1 fertile normozoospermic males were investigated. The mean frequency of structural chromosome aberrations in amorphous, motile spermatozoa was similar to that of morphologically normal sperm (9 vs. 7.7%). The structural aberrations found in amorphous, immotile spermatozoa reached 93% and revealed severity was significant. CONCLUSIONS: Teratozoospermia per se did not increase the frequency of structural chromosome aberrations in sperm. Severe chromosomal damage was revealed when immotile spermatozoa were injected into oocytes by ICSI.
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