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  • Title: Coniosetin, a novel tetramic acid antibiotic from Coniochaeta ellipsoidea DSM 13856.
    Author: Segeth MP, Bonnefoy A, Brönstrup M, Knauf M, Schummer D, Toti L, Vértesy L, Wetzel-Raynal MC, Wink J, Seibert G.
    Journal: J Antibiot (Tokyo); 2003 Feb; 56(2):114-22. PubMed ID: 12715870.
    Abstract:
    The coprophilic ascomycete Coniochaeta ellipsoidea DSM 13856 forms the new antibiotic coniosetin (1) in surface cultures grown on a medium containing malt extract and oatmeal. The structure of the compound C25H35NO4, MW 413, was determined by 2D-NMR and mass spectrometric studies. Coniosetin belongs to the class of tetramic acids; it consists of a substituted aliphatic bicyclic ring system linked to a tetramic acid subunit through a carbonyl center. The absolute configuration was determined by measuring its circular dichroism spectrum and comparing the data with those of equisetin. Coniosetin has a pronounced antibacterial and antifungal action, inhibiting even multi drug-resistant strains of Staphylococcus aureus at a concentration of 0.3 microg/ml, though it is inactive against Gram-negative bacteria.
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