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  • Title: [Preliminary study on hepatitis B virus quasispecies in a patient with chronic hepatitis B].
    Author: Lan L, Wang YM, Huang YP.
    Journal: Zhonghua Gan Zang Bing Za Zhi; 2003 Apr; 11(4):219-21. PubMed ID: 12716520.
    Abstract:
    OBJECTIVE: To investigate whether the hepatitis B virus (HBV) has quasispecies character by studying nucleotide sequence polymorphism and mutation features of HBV PreC/C gene region, and preliminaryly explore the heterogeneity of HBV quasispecies. METHODS: The serum sample was obtained from a patient with chronic hepatitis B, and the whole HBV PreC/C gene region was amplified by PCR and cloned. Thirty-four clones that contained HBV PreC/C gene fragments were sequenced. RESULTS: There were 28 kinds of different nucleotide sequences in 34 clones, and the nucleotide sequences diversity ranged from 0.2% to 2.1%. The mutation points were almost distributed in the whole region, but there wasn't mutation at PreC region nt.1 896 point in all sequences. CONCLUSION: Hepatitis B virus has complex quasispecies character in the patients with chronic hepatitis B.
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