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  • Title: In vitro susceptibility of Aspergillus spp. clinical isolates to albendazole.
    Author: Berthet N, Faure O, Bakri A, Ambroise-Thomas P, Grillot R, Brugère JF.
    Journal: J Antimicrob Chemother; 2003 Jun; 51(6):1419-22. PubMed ID: 12716778.
    Abstract:
    The in vitro antifungal activity of albendazole, a benzimidazole widely used as an antihelmintic drug in humans, was investigated and assessed for its activity against Aspergillus spp. Forty-eight isolates, representing the most frequent species found in human pathology [Aspergillus fumigatus (n = 27), Aspergillus flavus (n = 10), Aspergillus terreus (n = 7), Aspergillus nidulans (n = 3) and Aspergillus niger (n = 1)], and one quality control strain (A. niger ATCC 9804 83435) were tested according to the NCCLS M38-P methodology for moulds. All the strains were susceptible to albendazole, with homogeneous MICs for each species; three strains were resistant to itraconazole.
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