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  • Title: Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"?
    Author: Nettles KW, Greene GL.
    Journal: Mol Cell; 2003 Apr; 11(4):850-1. PubMed ID: 12718871.
    Abstract:
    Farnesoid X receptor (FXR) is a bile acid sensor that regulates lipid homeostasis. New structural data suggest that, unlike other nuclear receptors, FXR contains a second coactivator binding site and binds bile acids with the steroid backbone flipped head to tail, both of which have important functional ramifications.
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