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  • Title: Changes in blood viscosity with synthetic protease inhibitors.
    Author: Hitosugi M, Niwa M, Takahashi T, Kurosu A, Nihei H, Nagai T, Tokudome S.
    Journal: J Pharmacol Sci; 2003 Apr; 91(4):334-6. PubMed ID: 12719663.
    Abstract:
    We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently.
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