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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Bleomycin-mediated electrochemotherapy in mouse NR-S1 carcinoma.
    Author: Kitamura A.
    Journal: Cancer Chemother Pharmacol; 2003 Apr; 51(4):359-62. PubMed ID: 12721764.
    Abstract:
    PURPOSE: To determine whether or not low-voltage electrochemotherapy has cell killing effects. MATERIALS: Dorsally transplanted NR-S1 carcinomas in mice were stimulated with electric pulses (40 V/cm) after bleomycin (1 microg/g) had been injected around them. The tumors were fixed with a forceps electrode and electroporation was carried out three times a day for 4 days per week for 2 weeks. RESULTS: After 8 weeks of experimentation, the tumor had disappeared in four of the ten mice. The cell killing effects were mainly apoptosis and necrosis. CONCLUSION: Electroporation should be clinically introduced into the cosmetic and functional treatment of the head and neck region. Further investigation is also necessary to determine suitable carcinostatic agents and clarify the electric pulse conditions.
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