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  • Title: [Hormonal abnormalities in women with breast cysts].
    Author: Wypych K, Kuźlik R, Wypych P.
    Journal: Ginekol Pol; 2002 Nov; 73(11):1117-25. PubMed ID: 12722409.
    Abstract:
    OBJECTIVES: Increased estrogen activity and prolactin hypersecretion is a hormonal reason for Benign Breast Diseases. DESIGN: To evaluate hormonal disorders in women with gross breast cysts. MATERIAL AND METHODS: 30 women with gross breast cysts (over 10 mm in diameter) have been investigated. Cytohormonal vaginal swabs and serum levels of prolactin, estradiol and gonadotropins were evaluated. RESULTS: Normal prolactin levels were found in 96.7% of cases, but in 8 women with recurrent breast cysts after repeated FNA-biopsies prolactin secretion stimulated by metoclopramide was significantly increased. Low progesterone activity in all women and low estrogen activity in 65.3% were shown. Absolute high estrogen activity was diagnosed only in 8.7% women with gross breast cysts. CONCLUSIONS: Nearly all patients with gross breast cysts have normal prolactin and low progesterone levels. High estrogen levels appear very seldom and in most cases these patients are hypoestrogenic.
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