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  • Title: Cytokine abnormalities in a patient with eosinophilic fasciitis.
    Author: Dziadzio L, Kelly EA, Panzer SE, Jarjour N, Huttenlocher A.
    Journal: Ann Allergy Asthma Immunol; 2003 Apr; 90(4):452-5. PubMed ID: 12722970.
    Abstract:
    BACKGROUND: Eosinophilic fasciitis (EF) and peripheral eosinophilia are rare in children. OBJECTIVE: To describe a case of EF in a 3-year-old child who presented with acute painless induration of her forearm. METHODS: Cytokine profiles were obtained and compared with patients with atopic disease during the acute presentation and after treatment with low-dose prednisone. RESULTS: The patient's serum showed elevation of transforming growth factor beta1 and interleukin-5, which improved after treatment with low-dose prednisone. CONCLUSIONS: The case suggests that patients with EF have cytokine abnormalities similar to atopic patients, but with a striking elevation of transforming growth factor beta1. The responsiveness of the clinical symptoms and cytokine profile to low dose prednisone supports treatment with low dose immunosuppressive therapy in this disorder.
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